July 30, 2015
Dr. Marc Claret, head of the IDIBAPS group Neural Control of Metabolism, has received one of 63 BBVA Foundation Grants to Researchers and Culture Creators in the 2015 edition. The project of Dr. Claret is focused in finding molecular alterations in certain brain circuits, specifically in the hypothalamus, involved in the development of obesity and diabetes.
July 29, 2015
Doctors and researchers from Hospital Clínic and IDIBAPS were awarded in the second Vall d’Hebron Research Institute (VHIR) Health Innovation Contest. The first prize in the Healthcare Practice Innovation category was given to the project "Development of a surgical device for sutureless vascular anastomosis" led by Dr. Jordi Descarrega, third year resident at the Plastic, Reconstructive and Aesthetic Surgery Department of the Hospital Clinic. In the Biomedical Research Innovation category, the second prize was to the project "Liver on a Chip" led by Dr. Jordi Gracia-Sancho, Ramón y Cajal Researcher in the Liver hemodynamics and portal hypertension IDIBAPS team.
July 22, 2015
A study, published today in the journal Nature, marks a milestone in the understanding of chronic lymphocytic leukemia, the most common leukemia in adults, as the genomes of normal and tumor cells for more than 500 patients have been sequenced providing novel mechanisms involved in the development of this tumor. Cancer originates due to the progressive accumulation of mutations in the genome of normal cells. This is why seven years ago the International Cancer Genome Consortium (ICGC) was established. The main aim of this consortium was to sequence the genome of tumor cells from at least 500 patients, and do it for each of the 50 most frequent types of cancer in the world. The Spanish-led consortium in charge of the chronic lymphocytic leukemia study has been the first team to accomplish this ambitious objective. In this work, led by Dr. Carlos Lopez-Otin, from the University of Oviedo and by Dr. Elias Campo, from Hospital Clinic, IDIBAPS and University of Barcelona, more than 60 researchers from different centers have collaborated to mine the three billion bases of each tumor genome in search of alterations responsible for the development of this disease.
July 20, 2015
The normal lung development in early childhood is crucial in preventing Chronic Obstructive Pulmonary Disease
A study published in the New England Journal of Medicine (NEJM) shows that abnormal lung development before 40 years of age predisposes to a diagnosis of Chronic Obstructive Pulmonary Disease (COPD) 20 years later. Traditionally it was considered that COPD was a self-inflicted disease by smoking. This study shows that this is true in about half the cases but in the other half, abnormal lung development in the early years of life (and probably during pregnancy) is a very important risk factor. Dr. Àlvar Agustí, head of the Institute Clínic of Thorax at Hospital Clínic and of the IDIBAPS team Inflammation and repair in respiratory illnesses, member of the Networked Biomedical Research Center for Respiratory Diseases (CIBERES) and founding president of the Barcelona Respiratory Network (BRN), is one of three co-directors of the study.
July 13, 2015
Researchers from IDIBAPS describe a molecular mechanism linking the development of type 2 diabetes with the malfunction of a cell organelle, the endoplasmic reticulum, in a type of neurons called POMC found in the hypothalamus. The key is the altered processing of alpha-MSH, a neuropeptide that is produced exclusively in this type of neurons, which increases the amount of glucose produced in the liver. The study, published in the journal Cell Reports, is led by Dr. Marc Claret, researcher at the IDIBAPS Laboratory of Diabetes and Obesity. Dr. Marc Schneeberger and Dr. Alicia Gómez-Valadés are the first authors of the article.