March 3, 2015
A study published in the journal Proceedings of the National Academy of Sicences (PNAS), and led by researchers from IDIBAPS, explains why neurons have a correlated activity, ie, why they do not act in independently, and the fact that a neuron emits a pulse makes the others do it. Researchers have discovered that this is because during short periods the brain mutes its activity and neurons stop firing pulses at the same time. Dr. Jaime de la Rocha, head of the Cortical Circuit Dynamics group at IDIBAPS, is the article’s lead author. The first one is Dr. Gabriela Mochol.
February 17, 2015
The use of corticosteroids, a group of anti-inflammatory drugs, along with antibiotics, significantly reduces treatment failure among patients with severe community-acquired pneumonia from 31% to 13 %, at the same time that improves their prognosis. The Journal of the American Medical Association (JAMA) publishes this study led by researchers from Hospital Clínic of Barcelona, IDIBAPS and the Networked Biomedical Research Center for Respiratory Diseases (CIBERES). Dr. Antoni Torres, Pneumologist at Hospital Clínic of Barcelona, professor at the University of Barcelona and coordinator of the IDIBAPS and CIBERES group that has led this research, is the first author of the paper.
February 4, 2015
IDIBAPS researchers have established a mathematical model that confirms that the decision-making mechanism after a visual stimulus is based on the cyclical connection between the two types of neurons involved in this process. This research, published today in the journal Nature Communications, results from the collaboration between two research groups at IDIBAPS headed by Dr. Jaime de la Rocha and Dr. Albert Compte. Dr. Klaus Wimmer is the first author of this publication.
January 26, 2015
The stabilization of new lipid mediators derived from omega-3 fatty acids reduces the liver inflammation caused by obesity
The non-alcoholic steatohepatitis (NASH), also known as fatty liver disease, is a disease associated with obesity characterized by an accumulation of fat in liver cells accompanied by an inflammatory process that causes lesions similar to those suffered by people who consume alcohol in toxic amounts. A study led by Dr. Joan Clària, researcher at the IDIBAPS group Pathophysiology and treatment of ascites and altered renal function in liver cirrhosis, and consultant of the Biochemistry and Molecular Genetics Department at Hospital Clínic, demonstrates, for the first time, that the inhibition of the enzyme responsible for the degradation of lipid mediators derived from omega-3 can modulate inflammation associated with fat accumulation in the liver. In addition, these compounds, called epoxides, make liver cells able to eliminate fat through autophagy. This study, published in the journal Proceedings of the National Academy of Sciences (PNAS), has been carried out in collaboration with researchers from the University of California (Davis). The first author of the work is Cristina López-Vicario, predoctoral researcher of the IDIBAPS group.
January 22, 2015
A study led by researchers from IDIBAPS and funded by the aecc-Cataluña against Cancer in Barcelona has identified, for the first time, two genetic alterations that occur in intrahepatic cholangiocarcinoma (ICCA) and may represent a therapeutic target. Furthermore, they have mapped all the molecular alterations that occur in this type of liver cancer and they have found that 70% of patients have at least one of them. Dr. Josep M. Llovet, ICREA Research Professor at the HCC Translational Research Lab of the Liver Unit at IDIBAPS and Director of Mount Sinai Liver Cancer Program at the Icahn School of Medicine at Mount Sinai (New York), and Dra. Daniela Sia, researcher at the same group, are the principal investigator and the first author of the paper published in the journal Nature Communications. Dr. Josep Fuster, from the IDIBAPS Hepatic Oncology team and Surgery Professor has also participated in the study.