January 26, 2015
The stabilization of new lipid mediators derived from omega-3 fatty acids reduces the liver inflammation caused by obesity
The non-alcoholic steatohepatitis (NASH), also known as fatty liver disease, is a disease associated with obesity characterized by an accumulation of fat in liver cells accompanied by an inflammatory process that causes lesions similar to those suffered by people who consume alcohol in toxic amounts. A study led by Dr. Joan Clària, researcher at the IDIBAPS group Pathophysiology and treatment of ascites and altered renal function in liver cirrhosis, and consultant of the Biochemistry and Molecular Genetics Department at Hospital Clínic, demonstrates, for the first time, that the inhibition of the enzyme responsible for the degradation of lipid mediators derived from omega-3 can modulate inflammation associated with fat accumulation in the liver. In addition, these compounds, called epoxides, make liver cells able to eliminate fat through autophagy. This study, published in the journal Proceedings of the National Academy of Sciences (PNAS), has been carried out in collaboration with researchers from the University of California (Davis). The first author of the work is Cristina López-Vicario, predoctoral researcher of the IDIBAPS group.
January 22, 2015
A study led by researchers from IDIBAPS and funded by the aecc-Cataluña against Cancer in Barcelona has identified, for the first time, two genetic alterations that occur in intrahepatic cholangiocarcinoma (ICCA) and may represent a therapeutic target. Furthermore, they have mapped all the molecular alterations that occur in this type of liver cancer and they have found that 70% of patients have at least one of them. Dr. Josep M. Llovet, ICREA Research Professor at the HCC Translational Research Lab of the Liver Unit at IDIBAPS and Director of Mount Sinai Liver Cancer Program at the Icahn School of Medicine at Mount Sinai (New York), and Dra. Daniela Sia, researcher at the same group, are the principal investigator and the first author of the paper published in the journal Nature Communications. Dr. Josep Fuster, from the IDIBAPS Hepatic Oncology team and Surgery Professor has also participated in the study.
January 12, 2015
A study led by researchers from IDIBAPS shows, for the first time, that the induction in the liver of the transcription factor called KLF2 (Kruppel-like factor 2), a protein that promotes the expression of vasoprotective genes, significantly improves liver cirrhosis and portal hypertension. Dr. Jordi Gracia-Sancho, Ramón y Cajal researcher at the IDIBAPS group Liver hemodynamics and portal hypertension: Digestive bleeding secondary to ruptured esophageal varicose veins, and Dr. Jaume Bosch, director of the same team, have led this study published in the Gut journal whose first authorship share Giusi Marrone and Raquel Maeso-Díaz. This research was conducted in collaboration with a team from the Harvard Medical School & Brigham and Women's Hospital.
November 27, 2014
The art of urban natural drawing, or sketching, is a social and artistic phenomenon gaining adherents worldwide at great speed. The IDIBAPS has promoted over the past year, several activities to publicize the research that is carried out in the laboratories daily, through this artistic side. On November 20th, as part of Science Week in Catalonia, it was presented the final result of this project: the book Sketching científic IDIBAPS, the result of the two workshops in scientific sketching that have been carried out, one with professional Sketchers and the other, open to citizens.
November 24, 2014
The IDIBAPS hosted last week the course "Introduction to Research in Diabetes Mellitus", designed to promote awareness and interest about translational research for endocrinology in diabetes in senior residents and specialists in endocrinology. The course was organized by Dr. Anna Novials, who leads the IDIBAPS group Molecular and Metabolic Alterations in Diabetes and is the vice-president at the Spanish Diabetes Society (EDS), and consisted in theorical and practical classes about recent advances in biomedicine, metabolic study of patients and the basis of genetics and epigenetics of diabetes.