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News

  • July 22, 2015

    Mutations in the dark side of the genome cause leukemia

    A study, published today in the journal Nature, marks a milestone in the understanding of chronic lymphocytic leukemia, the most common leukemia in adults, as the genomes of normal and tumor cells for more than 500 patients have been sequenced providing novel mechanisms involved in the development of this tumor. Cancer originates due to the progressive accumulation of mutations in the genome of normal cells. This is why seven years ago the International Cancer Genome Consortium (ICGC) was established. The main aim of this consortium was to sequence the genome of tumor cells from at least 500 patients, and do it for each of the 50 most frequent types of cancer in the world. The Spanish-led consortium in charge of the chronic lymphocytic leukemia study has been the first team to accomplish this ambitious objective. In this work, led by Dr. Carlos Lopez-Otin, from the University of Oviedo and by Dr. Elias Campo, from Hospital Clinic, IDIBAPS and University of Barcelona, more than 60 researchers from different centers have collaborated to mine the three billion bases of each tumor genome in search of alterations responsible for the development of this disease.

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  • July 20, 2015

    The normal lung development in early childhood is crucial in preventing Chronic Obstructive Pulmonary Disease

    A study published in the New England Journal of Medicine (NEJM) shows that abnormal lung development before 40 years of age predisposes to a diagnosis of Chronic Obstructive Pulmonary Disease (COPD) 20 years later. Traditionally it was considered that COPD was a self-inflicted disease by smoking. This study shows that this is true in about half the cases but in the other half, abnormal lung development in the early years of life (and probably during pregnancy) is a very important risk factor. Dr. Àlvar Agustí, head of the Institute Clínic of Thorax at Hospital Clínic and of the IDIBAPS team  Inflammation and repair in respiratory illnesses, member of the Networked Biomedical Research Center for Respiratory Diseases (CIBERES) and founding president of the Barcelona Respiratory Network (BRN), is one of three co-directors of the study.

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  • July 13, 2015

    Alterations in a specific type of neurons are related with type 2 diabetes

    Researchers from IDIBAPS describe a molecular mechanism linking the development of type 2 diabetes with the malfunction of a cell organelle, the endoplasmic reticulum, in a type of neurons called POMC found in the hypothalamus. The key is the altered processing of alpha-MSH, a neuropeptide that is produced exclusively in this type of neurons, which increases the amount of glucose produced in the liver. The study, published in the journal Cell Reports, is led by Dr. Marc Claret, researcher at the IDIBAPS Laboratory of Diabetes and Obesity. Dr. Marc Schneeberger and Dr. Alicia Gómez-Valadés are the first authors of the article.

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  • July 13, 2015

    Researchers discover new applications of the drug fingolimod to improve cognitive deficits in Huntington’s disease

    Fingolimod, a drug used to treat multiple sclerosis, restores hippocampal synaptic plasticity and improves memory function. This is the main conclusion of a study developed by researchers at the University of Barcelona (UB) and the IDIBAPS in a mouse model of Huntington disease (HD). The study has been published in the journal Human Molecular Genetics and highlighted by the journal Nature Reviews Neurology. The study is led by Dr. Jordi Alberch head of the Consolidated Research Group on Pathophysiology of Neurodegenerative Diseases of the UB and researcher at IDIBAPS. The first author is Dr. Andrés Míguez, researcher in Dr. Alberch’s group hired through the BIOTRACK Programme, an IDIBAPS project to incorporate postdoctoral researchers funded by the European Commission through the Marie Curie Actions (COFUND category).

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  • July 13, 2015

    The book “Sketching científic IDIBAPS” arrives to the public libraries of Catalonia

    Throughout 2014 IDIBAPS promoted several activities to publicize the research develop in its laboratories through the urban natural drawing (urban sketching). The result of this project was the book Sketching científic IDIBAPS, presented last November in the context of the Science Week, and now comes to the society through the donation of 150 copies to the public libraries of Catalonia. For this reason the book was presented on July 9 in the Sagrada Familia Library. Under the title "Scientific divulgation in libraries?" the event was attended by Pastora Martínez, manager of IDIBAPS, Carmen Fenoll, head of the Library Service of the Department of Culture of the Generalitat of Catalonia, and Marc Boada, science commentator.

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