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News

  • June 7, 2019

    A new molecular mechanism could explain the origins of the depressive symptoms in Huntington’s disease

    About 40 % of the affected patients with Huntington’s disease –a neurodegenerative pathology- show depression symptoms, even in early stages before the apparition of the typical motor symptoms of the disease. An altered function of Cdk5 kinase –an essential enzyme in several cell signalling pathways- could explain the physiopathology of the depressive-like behaviour in Huntington’s disease, according to a pre-clinical study in which Sílvia Ginés, Verónica Brito, Albert Giralt and Jordi Alberch from the Faculty of Medicine and Health Sciences, the Institute of Neurosciences of the UB (UBNeuro) and researchers of the Pathophysiology and treatment of neurodegenerative disorders IDIBAPS research group, have taken part.

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  • April 17, 2019

    A protein involved in cancer protects against muscle diseases

    Researchers from the IDIBAPS Research Institute have found that the protein known as ZEB1 have beneficial or deleterious effects depending on its levels and the tissue where is expressed. Previous studies from the same group had shown that the uncontrolled increase of ZEB1 contributes to the development of different types of cancers. However, the new studies from the group show that ZEB1 protects the muscle from atrophy and muscular dystrophy.

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  • April 2, 2019

    Anti-platelet therapy prevents the progression of fatty liver to liver cancer in animal models

    A study published in the journal Nature Medicine proposes a paradigm shift in the approach to steatohepatitis, the most advanced degree of non-alcoholic fatty liver disease, one of the diseases responsible for the increase in the incidence of liver cancer.

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  • March 5, 2019

    Researchers at IDIBAPS describe how aging aggravates liver diseases

    IDIBAPS researchers have published a series of three studies in which describe the impact of aging on the liver biology and function, both in healthy individuals and in the context of different liver diseases. The works show that the progression and response to treatments is not the same in older people as in young people, demonstrating that aging causes a faster aggravation of liver disease and a worse response to therapies. In addition, it is described for the first time that the molecular signature of liver disease is different in older patients compared to young people.

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  • February 20, 2019

    Astrocytes play a key role in the survival of neurons

    Researchers from IDIBAPS have participated in a study led by the Institute of Neurosciences of the University of Barcelona (UBNeuro) in which a potential therapeutic strategy to treat Alzheimer’s has been identified. The study, published in Journal of Neuroscience, shows in a model of the illness in mice, that astrocytes –a type of cells in the brain- are able to release proteins that favour survival of neurons. According to the researchers, these results are a step forward in the understanding of the physiology of astrocytes, and they bring the chance to use this type of cells in therapeutic ways to treat Alzheimer’s disease.

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