Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS - News A protein involved in cancer protects against muscle diseases

Researchers from the IDIBAPS Research Institute have found that the protein known as ZEB1 have beneficial or deleterious effects depending on its levels and the tissue where is expressed. Previous studies from the same group had shown that the uncontrolled increase of ZEB1 contributes to the development of different types of cancers. However, the new studies from the group show that ZEB1 protects the muscle from atrophy and muscular dystrophy. ]]>
April 17, 2019
Anti-platelet therapy prevents the progression of fatty liver to liver cancer in animal models A study published in the journal Nature Medicine proposes a paradigm shift in the approach to steatohepatitis, the most advanced degree of non-alcoholic fatty liver disease, one of the diseases responsible for the increase in the incidence of liver cancer. ]]> April 2, 2019 Researchers at IDIBAPS describe how aging aggravates liver diseases IDIBAPS researchers have published a series of three studies in which describe the impact of aging on the liver biology and function, both in healthy individuals and in the context of different liver diseases. The works show that the progression and response to treatments is not the same in older people as in young people, demonstrating that aging causes a faster aggravation of liver disease and a worse response to therapies. In addition, it is described for the first time that the molecular signature of liver disease is different in older patients compared to young people. ]]> March 5, 2019 Astrocytes play a key role in the survival of neurons Researchers from IDIBAPS have participated in a study led by the Institute of Neurosciences of the University of Barcelona (UBNeuro) in which a potential therapeutic strategy to treat Alzheimer’s has been identified. The study, published in Journal of Neuroscience, shows in a model of the illness in mice, that astrocytes –a type of cells in the brain- are able to release proteins that favour survival of neurons. According to the researchers, these results are a step forward in the understanding of the physiology of astrocytes, and they bring the chance to use this type of cells in therapeutic ways to treat Alzheimer’s disease. ]]> February 20, 2019