Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS - News A new molecular mechanism could explain the origins of the depressive symptoms in Huntington’s disease About 40 % of the affected patients with Huntington’s disease –a neurodegenerative pathology- show depression symptoms, even in early stages before the apparition of the typical motor symptoms of the disease. An altered function of Cdk5 kinase –an essential enzyme in several cell signalling pathways- could explain the physiopathology of the depressive-like behaviour in Huntington’s disease, according to a pre-clinical study in which Sílvia Ginés, Verónica Brito, Albert Giralt and Jordi Alberch from the Faculty of Medicine and Health Sciences, the Institute of Neurosciences of the UB (UBNeuro) and researchers of the Pathophysiology and treatment of neurodegenerative disorders IDIBAPS research group, have taken part. ]]> June 7, 2019 A protein involved in cancer protects against muscle diseases

Researchers from the IDIBAPS Research Institute have found that the protein known as ZEB1 have beneficial or deleterious effects depending on its levels and the tissue where is expressed. Previous studies from the same group had shown that the uncontrolled increase of ZEB1 contributes to the development of different types of cancers. However, the new studies from the group show that ZEB1 protects the muscle from atrophy and muscular dystrophy. ]]>
April 17, 2019
Anti-platelet therapy prevents the progression of fatty liver to liver cancer in animal models A study published in the journal Nature Medicine proposes a paradigm shift in the approach to steatohepatitis, the most advanced degree of non-alcoholic fatty liver disease, one of the diseases responsible for the increase in the incidence of liver cancer. ]]> April 2, 2019