Selective gene function modification to promote kidney regeneration

REF: PhD 09
Postdoctoral Research Fellow
Hours of work:
37.5 hours per week (exluding lunch hours)
Annual leave:
24 days per annum plus statutory days
Villarroel 170, 08036 Barcelona
Accountable to:
Professor Georgina Hotter
Up to 3 years, by IDIBAPS
38.000 € plus housing facilities


Job summary

1. A postdoctoral position is available in Professor Georgina Hotter laboratory. The position involves working wit a team of scientists studying kidney regeneration therapies through genetic and cell therapy manipulation.

The programme is a continuation of work recently published in

Vinuesa et al J Pathol, 2008, 214:104 Macrophage involvement in the kidney repair phase after ischaemia/reperfusion injury, which has provided evidence of endogenous regeneration after ischemia reperfusion through cell therapy.

Briefly, results obtained in a European project leaded by the group, where we have identified regenerative genes involved in kidney regeneration after acute renal failure. Thus, we aim to enhance regeneration using this knowledge and more exactly through genetic manipulation of the identified genes.

The purpose of this programme of work will be to enhance kidney regeneration through gene manipulation in different cell types in order to promote regenerative cell therapy

2. The project is likely to involve some or all of the following techniques:

  • promoter analysis
  • gene silencing
  • gene overexpression
  • molecular biology and cell signalling

Main Duties

To conduct research investigating cell therapy experiments with gene over expression or gene silencing

Duties and Responsabilities

  • To contribute to the design and planning of experiments in relation to this project
  • To develop a thorough understanding of the research field and be involved in the intellectual decision making process required for successful completion of the project
  • To set up and run experiments in consultation with the Principal Investigator
  • To record, analyse and write up the results of experiments and ensure that laboratory notebooks are kept fully up to date as a formal record of the research
  • To prepare and present findings of research to the Principal Investigator and other members of the centre
  • To prepare progress reports on research
  • The post holder may be required to perform some limited teaching and/or supervision of other members of staff and/or students, under the guidance of the Principal Investigator
  • Responsible for ensuring that designated equipment is safe and maintained in good working order
  • As duties and responsibilities change, the job description will be reviewed and amended in consultation with the post holder
  • The post holder will carry out any other duties that are within the scope, spirit and purpose of the job, as requested by the Principal Investigator

Person specification

Knowledge and Qualifications
  • Undergraduate degree in a life science discipline
  • PhD in an appropiate life science discipline
  • Basic knowledge of cell biology, biomedicine, expertise in one or more of the following: cell therapy or gene therapy
  • Publications in high impact factor peer reviewed journals
  • Abilitity to develop ideas logically and design experiments to test hypotheses
  • Ability to modify and apply new methods to advance a project
  • Ability to analyse and write up data for presentations and publications
  • Ability to present complex information effectively to a range of audiences
  • Effective written and verbal communication skills
  • Ability to meet deadlines
  • Record of delivering high quality research
  • Research skills in molecular cell signalling,
  • Expertise in cell therapy or gene therapy
  • Ability to direct junior members of the laboratory in simple laboratory procedures

Experience of working in a research environment


Experience of multi-disciplinary working

Personal Qualities
  • Commitment to high quality research
  • Ability to work effectively as part of the team
  • Ability to work independently and to use own initiative when required
(Read eligibility criteria)