Biotrack

Pathogenic and molecular mechanisms of liver failure

REF: PD 17
Principle investigator:
Pere Ginès / Vicente Arroyo
Contact details:

pgines(ELIMINAR)@clinic.ub.es

RESEARCH LINE NO LONGER AVAILABLE

Research framework

A postdoctoral position is available in Professor Pere Ginès laboratory. The position involves working in a multidisciplinary team of scientists studying the molecular pathogenesis of liver failure. The group lead by Dr. Pere Ginès has more than 20 years of experience in the clinical management and research in cirrhosis and has produced major advances in the field. The liver laboratory has large experience in molecular and cell biology and animal models of liver disease and has made significant contributions on mechanisms of liver fibrogenesis.

The project will investigate the molecular processes that take place during progression of cirrhosis by using a systems biology approach to gain insights into the pathogenesis of human cirrhosis. The project is aimed at unveiling not only the cellular and molecular mechanisms associated with cirrhosis progression through different stages of the disease, but also the relationship between extrahepatic factors and progression of liver disease, and the relationship between liver failure and dysfunction of organs distant from the liver, eventually leading to multi-organ failure.

The study will use high-throughput techniques to analyze liver samples from patients with cirrhosis at different stages of the disease and assess metabolic networks relevant to disease progression as well as the possible influence of extrahepatic factors. Studies in experimental models of liver disease and liver cells will also be performed to answer specific questions. The relevance of the potential points of intervention in the pathogenesis of cirrhosis progression will then be confirmed in studies using cell cultures and experimental models of cirrhosis.

The project is likely to involve some or all of the following techniques:

  • Translational studies in samples of liver tissue from patients with liver failure
  • Manage of high throughput data of gene expression and metabolomics.
  • Molecular biology techniques
  • Studies in animal models of liver diseases
  • Cell culture techniques

Keywords

Liver failure, Cirrhosis, translational research, Systems biology, Targets for therapy

Main Challenges

  • To contribute to the design and planning of experiments in relation to this project.
  • To acquire the ability to work independently and to use own initiative.
  • To prepare and present findings of research to scientific community.
  • To perform teaching and supervision of other members of staff and/or students.
  • To work in a research environment and commitment to high quality research
  • To work as part of a multi-disciplinary but leading your research line. All the members of the team will collaborate in this research project.

Team strategic objective in IDIBAPS

This is an interdisciplinary group that investigates the mechanisms and treatment of liver fibrotic inflammation leading to cirrhosis, as well as the pathogenesis and treatment of the multiorgan complications derived from the existence of established liver cirrhosis.

(Read eligibility criteria)