Biotrack

Molecular Pathology of Lymphoid Neoplasm

REF: PD 31
Principle investigator:
Elías Campo
Contact details:

ecampo(ELIMINAR)@clinic.ub.es

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Research framework

The purpose of this program is to study the alterations of the molecular mechanisms of lymphoid neoplasms and their correlation to clinicopathological characteristics; and to perform functional studies of molecular factors that may contribute to tumor pathogenesis, and which therefore may be candidates for the development of novel diagnostic techniques.

The most common techniques used by the team are: immunohistochemistry, RNA Expression microarrays, oligo array CGH, statistical analysis of high-throughput genomic analysis, quantitative PCR, DNA sequencing, Laser micro-dissection, Fluorescent in situ hybridization, Flow cytometry, Cell sorting, and gene transduction to cell lines or primary cells.

The publications that support the research made are:

  1. Xargay-Torrent S, et al (2011).PLoS One 6(6):e21382.
    PMID: 21798649
  2. Navarro A, Campo E (2011) Ann Oncol 22(4): 32-5.
    doi:10.1093/annonc/mdr168
  3. Puente XS, et al (2011) Nature 475(7354):101-5.
    PMID: 21642962
  4. Garcia-Herrera A, et al (2011) Am J Surg Pathol 35(8):1214-1225.
    PMID: 21753698
  5. Mozos A, et al (2011) Am J Pathol. 2011 Nov;179(5):2601-10.
    PMID: 21907693
  6. Royo C, et al (2011) Semin Cancer Biol Nov;21(5):322-34.
    PMID: 21945515
  7. Navarro A, et al (2011) Semin Hematol 48(3):155-65. Review.
    PMID: 21782057
  8. Quesada V, et al (2011) Nat Genetics 44(1):47-52.
    PMID: 22158541
  9. Enjuanes A, et al (2012) Rheumatology (Oxford) May;51(5):841-51.
    PMID: 22258388
  10. Carvajal-Cuenca A, et al (2012) Haematologica Feb;97(2):270-8.
    PMID: 22058203
  11. Martinez A, et al (2012) Am J Surg Pathol Feb;36(2):296-304.
    PMID: 22251943
  12. López C, et al (2012) Br J Haematol Mar;156(5):612-8.
    PMID: 22150335
  13. Royo C, et al (2012) Leukemia Mar 19. [Epub ahead of print]
    PMID: 22425896
  14. López C, et al (2012) Genes Chromosomes Cancer May 23. [Epub ahead of print]
    PMID: 22619094
  15. López-Guerra M, et al. (2012) Leukemia Jun;26(6):1429-32.
    PMID: 22182921

The program is a continuation of the work published in the last years. The group has a long experience on this field, has a good network of international collaborations and participates in several national and international projects.

Keywords

Lymphoma, Leukemia, genes, prognosis

Main Challenges

The main challenges we would like to achieve are:

  1. Identification of copy number abnormality, genomic mutation and de-regulation of cancer associated genes in lymphoid neoplasms.
  2. Functional validation for the altered molecules identified in step #1.
  3. Clinico-pathological correlations of the altered molecules.
  4. Establishment of newly analytical methods based on the results of #1to #3. Application of the analytical methods for daily diagnosis of lymphoid neoplasms.

It is expected that the selected postdoctoral fellow is familiar with scientific methodologies described above and has abilities to perform experiments accurately, work independently, communicate effectively, and analyze critically. The person with experiences of surgical pathology would be preferable.

In concrete terms, the candidate will:

  • Contribute to the design and planning of experiments in relation to this project.
  • Set up and run experiments in consultation with the Principal Investigator.
  • Make a presentation about findings of research in domestic or international academic meetings.

The researcher will be under direct supervision of Dr. Elias Campo. The researcher will incorporate in a team working with several postdoctoral researchers that currently address other aspects of the molecular pathology of the lymphoid neoplasms.

Team strategic objective in IDIBAPS

Our strategic objectives are:

  • The identification of genetic and molecular mechanisms implicated in the development and progression of lymphoid neoplasms.
  • The development of strategies for transferring to clinical practice the knowledge generated by basic research on lymphoid neoplasms.
  • Identification of parameters allowing the improved diagnosis and prognosis of lymphoid neoplasms.

This study will develop the effective use of the recent progress of molecular biology in daily pathological diagnoses.

(Read eligibility criteria)