Research
Area 1
Immunoreceptors of the Innate and Adaptive System
Team manager
Francisco Lozano
(Hospital Clínic/UB)
FLOZANO(ELIMINAR)@clinic.ub.es
Strategic objectives
1. Genetic and molecular characterization of the receptors of the innate and adaptive immune system.
2. Functional characterization of the ligand-receptor interactions responsible for intracellular communication between components of the innate and adaptive immune system.
3. Molecular characterization of pathogen-host interactions.
4. Molecular characterization of the biology, pathogenesis and immunology of cytomegalovirus (CMV).
Main lines of research
1. Study of the structure and function of leukocyte molecules of the signalling lymphocytic activation molecule (SLAM) and SLAM-associated protein (SLAP) families.
2. Identification and characterization of leukocyte receptors and intracellular ligands of the adaptor molecule 3BP2. Molecular dissection of the signal pathways of 3BP2 in lymphocytes.
3. Study of molecules that play a role in leukocyte adhesion and inflammation.
4. Immunogenetics of receptors and molecules implicated in the regulation of the innate and adaptive immune responses.
5. Study of the role of CD5 and CD6 receptors in lymphocyte differentiation and activation.
6. Molecular and functional characterization of non-lymphoid members of the superfamily of receptors with extracellular dominions rich in cysteine, such as scavenger (scavenger receptor cysteine-rich, SRCR).
7. Characterization of gene regulation mechanisms of CMV and identification of functions coded for CMV.
8. Study of the modulation of the immune response due to CMV and immunoevasion strategies.