Research

Area 3

Pathophysiology and Treatment of Ascites and Renal Function Disorder in Cirrhosis of the Liver

Team manager
Vicente Arroyo
(Hospital Clínic)
VARROYO(ELIMINAR)@clinic.ub.es

Strategic objectives

This is an interdisciplinary group that investigates the mechanisms and treatment of the inflammation and liver fibrosis that lead to cirrhosis, and the pathogenesis and treatment of multi-organ complications deriving from established cirrhosis of the liver.

Main lines of research

1. Molecular determinants of liver inflammation. Role of Kupffer cells.

2. Acute bacterial infections in cirrhosis.

3. Pathophysiology and treatment of hepatorenal syndrome and renal failure associated with bacterial infections.

4. Evaluation of cirrhotic myocardiopathy.

5. Relationship between hepatic encephalopathy and abnormal renal function in cirrhosis.

6. Pathogenesis, clinical implications and treatment of hyponatremia.

7. Evaluation of different cerebral magnetic resonance techniques in cirrhotic patients. Relationship with hepatic encephalopathy.

8. Role of endogenous cannabinoids in the pathophysiology of arterial vasodilation.

9. Application of genomics and gene therapy in liver dysfunction.

10. Angiogenesis, edema and vascular remodeling in cirrhosis of the liver.

11. Pathogenesis of liver fibrosis: cellular bases and identification of new therapeutic strategies.

12. Pathophysiology and treatment of arterial vasodilation.

13. Pathophysiology and treatment of ascites.

14. Artificial liver support systems.