Research
Area 3
Diabetes: Metabolic and Molecular Networks
Team manager
Ramon Gomis
(Hospital Clínic)
RGOMIS(ELIMINAR)@clinic.ub.es
Strategic objectives
1. Investigate the molecular determinants of the pancreatic beta cell that may play a role in the etiopathogenesis of diabetes, with special emphasis on those involved in the processes of apoptosis and cell regeneration.
2. Investigate the determinants of cell plasticity in diabetes and obesity: effect of different treatments in humans and experimental animals.
3. Investigate the molecular and metabolic mechanisms in increased cardiovascular risk in diabetes and obesity.
Main lines of research
1. Analysis of the transcription circuits that regulate the beta cell population and their function.
2. Description of the modulating effects of the transcription factors neuroD1 and neurogenin3 in embryonic pancreas development.
3. Description of the molecular pathways involved in the antiobesity and antidiabetic effects of tungstate in experimental animals.
4. Determine the role of kinases and phosphatases in diabetes and obesity.
5. Investigate the genetic and cellular determinants involved in the formation of amylin deposits and the associated beta cell dysfunction.
6. Determine the role of DMPK in the development of resistance to insulin and in other metabolic disorders.
7. Impact of normoglycemia in endothelial dysfunction: use of therapies involving insulin pumps.