Research
Area 2
Pathophysiologic Mechanisms of Respiratory Diseases
Team manager
Joan Albert Barberà
(Hospital Clínic)
JBARBERA(ELIMINAR)@clinic.ub.es
Strategic objectives
1. Investigation of the molecular and cellular bases of chronic respiratory diseases, with special interest in pulmonary circulation disorders and systemic manifestations.
2. Study of the pathophysiologic and pathogenetic mechanisms related to acute and chronic respiratory failure, focusing on chronic obstructive diseases, liver and lung disorders and obesity.
3. Evaluation of the potential of cell therapy and tissue engineering applied to respiratory diseases.
4. Development of artificial and bioartificial lung models for supporting patients with acute and chronic respiratory failure.
5. Study of the factors that determine the clinical course and use of health care resources in patients with chronic respiratory diseases.
Main lines of research
1. Biopathology and physiopathology of lung circulation disorders.
2. Physical activity, cell bioenergetics and systemic effects of chronic obstructive pulmonary disease (COPD).
3. Pathophysiologic mechanisms of abnormal gas exchange in obstructive diseases of the airways.
4. Interaction between systemic and pulmonary inflammation in COPD and morbid obesity.
5. Tissue engineering and bioartificial lung models.
6. Factors that determine the clinical course and use of health care resources in patients with chronic respiratory diseases.
7. Analysis of inflammation and oxidative stress biomarkers in exhaled air for the study of respiratory diseases.