Research

Area 2

Clinical and Experimental Respiratory Immunoallergy (IRCE)

Team manager
César Picado
(Hospital Clínic, Universitat de Barcelona)
CPICADO(ELIMINAR)@clinic.ub.es

Strategic objectives

1. To investigate the mechanisms that regulate the inflammatory response and remodeling in bronchial asthma, rhinosinusitis and pulmonary interstitial diseases.

2. To investigate the mechanisms responsible for food allergies.

3. To investigate the mechanisms involved in anaphylaxis of complex etiopathogenesis.

4. To investigate the mechanisms involved in loss of sense of smell.

Main lines of research

1. Molecular and cellular bases of the inflammatory response in asthma, rhinosinusitis and pulmonary interstitial diseases.

2. Role of MUC genes in the regulation of mucus secretion in respiratory diseases and their regulation by glucocorticoids.

3. Role of arachidonic acid metabolites (prostaglandins and leukotrienes) in the pathogenesis of asthma, chronic rhinosinusitis and pulmonary interstitial diseases.

4. Role of the angiotensin system in pulmonary fibrosis.

5. Study of the mechanisms that regulate the response to treatment with glucocorticoids in respiratory inflammatory diseases.

6. Study of the mechanisms involved in severe asthma and their link to abnormal functioning of the glucocorticoid receptor.

7. Study of the interrelation between diseases of the upper respiratory tract (nose and sinus) and the lower respiratory tract (asthma, bronchiectasis, chronic obstructive pulmonary disease).

8. Study of the mechanisms that regulate the response to food allergens and their link to nonsteroidal anti-inflammatory drugs and the metabolism of arachidonic acid.

9. New therapeutic modalities (endothelin inhibitors, proteasome and COX-2 inhibitors, and prostaglandin E2 receptor-3 agonists) in asthma, rhinosinusitis and pulmonary interstitial disease using in vitro models and animal models of asthma and pulmonary fibrosis.

10. Study of the mechanisms of anaphylactic reactions of multiple origins (indolent mastocytosis, predisposing genetic disorders).

11. Study of quality of life in nasal sinus pathology.

12. Loss of sense of smell: role of nasal sinus inflammation ,Parkinson disease and congenital disorders.