Area 3

Gynecological endocrinology and human reproduction

Team leader

Strategic objectives

The global aim of this research group for the coming years is to advance in the knowledge of different aspects relating to the physiopathology of human reproduction: from endocrinological considerations to the most important benign and malignant pathological processes of the female reproductive system, as well as the investigation and treatment of human reproduction failure. More specifically, the main objectives of our research group are to advance in the existing lines of work, with the purpose of:

  1. Determining the most relevant mechanisms in the pathogenesis of reproductive failure (sterility, repeated miscarriages, repeated implant failure after in vitro fertilization) and of the principal female reproductive disease processes (endometriosis, uterine myoma, genital cancer).
  2. Optimizing and innovating as far as possible the preventive or therapeutic potential in the aforementioned situations

Main lines of research

  1. Reproductive failure markers
    Analysis of the possible role of new markers of hemostasis alterations as a new pathogenic mechanism of thrombotic disease in early and advanced pregnancy, in patients with or without antiphospholipid syndrome. Study is also made of the usefulness of immunohistochemical and quantitative and qualitative proteomic parameters in the human endometrium as markers of endometrial receptiveness. In-depth research of the pathogenic mechanisms involved in the block of pre-implantation embryonic development in vitro.
  2. Ovarian dysfunction and stimulation/hyperstimulation
    Investigation of the possibilities of ultrasound, hormonal, endocrinemetabolic and genetic markers in relation to the prediction of ovarian response. Study of the role of LH and the androgens as ovarian sensitizing factors in relation to ulterior stimulation with FSH. Investigation of the possible role of the ovarian follicular cells (granulosum, macrophages) in the pathogenesis of ovarian hyperstimulation syndrome, with the exploration of new ovarian stimulation or endometrial preparation protocols allowing improved results in assisted reproduction techniques.
  3. Optimization of the surgical management of diseases of the reproductive apparatus
    Designed to analyze the role of the surgical variables allowing improvement of the results and reduction of the morbidity in the surgical treatment of benign and malignant disorders of the female reproductive apparatus. This also implies defining the prognostic value of HPV (human papillomavirus) detection and viral typing as prognostic and progression markers of precancerous lesions of the cervix, vagina and vulva.