Research

Area 3

Metabolic regulation and molecular pathology

Team leader

  • Josep Carreras
    (Facultat de Medicina)

Strategic objectives

  1. Study of rabbit and rat muscle metabolism and proteome in fast and slow fibers, and the modifications associated with electrostimulation and training work.
  2. Use of biochemical markers to determine muscle damage.
  3. Study of the metabolic alterations of the transplanted heart and its preservation.
  4. Study of apoptosis extrinsic pathway in the transplanted heart and its blockage.

Main lines of research

  1. Study of the fast and slow muscle proteome in trained and sedentary rats.
  2. Metabolic analyses of human muscle biopsies in relation to training.
  3. Study of the serum fast and slow myosins as muscle damage markers. Effect of exercise in athletes and diabetics.
  4. Reversal of metabolic block in the transplanted heart based on TAT-FLIPS proteins.
  5. Use of TAT-FLIPS protein to block apoptosis in the transplanted heart.