Research

Area 4

Brain ischemia: Clinical and experimental studies

Team leader

Strategic objectives

Study of cerebrovascular pathology from the clinical and basic perspective, with special emphasis on inflammation and immune response, and oxidative stress, as well as on the use of neuroimaging techniques. The ultimate aim is to develop therapeutic strategies in application to stroke.

Main lines of research

Inflammation and immunity in stroke

  • Immunological mechanisms implicated in the progression of ischemic stroke and in the appearance of infectious complications. Study of inflammatory and innate immune responses in stroke. Genetic aspects of immune response. Studies of the lectin pathway.
  • Study of brain-derived antigens in secondary lymphoid organs and its involvement in brain damage after stroke
  • Relevance of adaptive immune responses in stroke outcome

Multimodal neuroimaging in Stroke

  • Neuroimaging in brain ischemia: application of magnetic resonance (MR), CT or optical imaging techniques for the in vivo noninvasive monitorization of patients and experimental animals in relation to anatomical and functional parameters of brain damage – including immune response. Application in the vascular dementia model and the studies of functional recovery after stroke.

Neuroprotection

  • Identification of new antioxidant treatments in stroke. Preclinical studies of the protective effects of these treatments and of the mechanisms involved. Design and conduction of a phase III study involving the administration of uric acid in stroke patients treated with rtPA.
  • Use of intraarterial rescue treatments with rtPA in patients previously treated with intravenous rtPA and selected by multimodal imaging techniques.
  • Neurological repair and neurogenesis in brain ischemia: effect of inflammation upon neurogenesis; experimental functional MRI.

Clinical trials

  • Combination of thrombolysis with antioxidants (uric acid).