Area 1

Immune receptors of the innate and adaptive system

Team leader

Strategic objectives

  1. Identification and characterization of functionally relevant genetic variations of immunoreceptors regulating innate and/ or adaptive immune responses.
  2. Functional characterization of the ligand-receptor interactions responsible for intercellular communication between components from the innate and adaptive immune system.
  3. Understanding of host-pathogen interactions mediated by lymphoid and non-lymphoid receptors.
  4. Development of novel immunomodulatory strategies in experimental models of autoimmunity, infection and cancer.
  5. Characterization of cytomegalovirus (CMV) biology and pathogenesis.

Main lines of research

  1. Study of the structure and function of the SLAM (Signaling Lymphocytic Activation Molecule) and SAP (SLAM-Associated Protein) leukocyte molecule families.
  2. Study of the molecules that intervene in leukocyte adhesion and inflammation.
  3. Immunogenetics of receptors and molecules implicated in the regulation of innate and adaptive immune responses.
  4. Study of the role of the lymphoid scavenger-like receptors CD5 and CD6 as immunomodulators in infection, autoimmunity and cancer.
  5. Molecular and functional characterization of nonlymphoid members of the superfamily of receptors with extracellular domains rich in cysteine (SRCR, Scavenger Receptor Cysteine-Rich) residues.
  6. Characterization of the mechanisms that regulate CMV gene expression and identification of functions encoded by CMV.
  7. Study of CMV modulation of the immune response and viral immune evasion strategies.