Area 1

Immunogenetics of the autoinflammatory response

Team leader

Strategic objectives

In the field of autoinflammatory diseases:
Promotion of basic, clinical and translation research in the physiopathology of autoinflammatory diseases as a model for gaining in-depth knowledge of the regulation of the normal inflammatory response, its dysfunctions, and its repercussions upon the immune response.

In the field of immune response:
Determination of the components of normal and pathological inflammatory response is essential for modulating the specific recognition phenomena of the immune response.

Main lines of research

In the field of autoinflammatory diseases:

  • Determination of the genetic and molecular bases of the autoinflammatory process.
  • Characterization of the regulatory mechanisms of the inflammasome and its dysfunction.
  • Characterization of the specific transcriptional profiles of autoinflammatory diseases.
  • Isolation of new genes responsible for hereditary autoinflammatory diseases and identification of genetic susceptibility factors for the development of polygenic autoinflammatory processes.
  • Definition of new therapeutic targets for the treatment of autoinflammatory diseases.

In the field of immune response:

  • Assessing the role of HLA-DRB3/4/5 loci in the immune response against infection, transplantation and autoimmune response.
  • Assessing the role of the mutation E52del in MyD88 in normal population as well as in relation to the lack of MyD88.