Research

Area 3

Physiopathology and treatment of ascites and altered renal function in liver cirrhosis.

Team leader

Strategic objectives

This is an interdisciplinary group that investigates the mechanisms and treatment of liver fibrotic inflammation leading to cirrhosis, as well as the pathogenesis and treatment of the multiorgan complications derived from the existence of established liver cirrhosis.

Main lines of research

  1. Molecular determinants of liver inflammation. Role of the Kupffer cells.
  2. Acute bacterial infections in cirrhosis.
  3. Physiopathology and treatment of hepatorenal syndrome and renal failure associated with bacterial infections.
  4. Evaluation of cirrhotic myocardiopathy.
  5. Relationship between hepatic encephalopathy and alterations in renal function in cirrhosis.
  6. Pathogenesis, clinical implications and treatment of hyponatremia.
  7. Evaluation of different brain MRI techniques in cirrhotic patients. Relationship to hepatic encephalopathy.
  8. Role of endogenous cannabinoids in the physiopathology of arterial vasodilatation.
  9. Application of genomics and gene therapy to liver dysfunction.
  10. Angiogenesis, endothelial dysfunction, edema and vascular remodeling in liver cirrhosis.
  11. Pathogenesis of liver fibrosis: cellular bases and identification of new therapeutic strategies.
  12. Physiopathology and treatment of arterial vasodilatation.
  13. Physiopathology and treatment of ascites.
  14. Artificial liver support systems.
  15. Identification of new therapeutic targets in alcoholic hepatitis.