Area 5

Cell proliferation and signaling

Team leader

  • Oriol Bachs

Strategic objectives

The general goal of the group is the analysis of the mechanisms involved in cell cycle progression and signalling in health and disease.

Main lines of research

1. Cell proliferation and Cancer: The objective of this line of research is the analysis of the mechanisms involved in cell cycle regulation and its alterations during tumorigenesis:

  • Role of theCKI p27(Kip1) on the regulation of transcription, splicing and translation of genes involved in tumorigenesis.
  • Cell cycle regulationbyprotein acetylation.
  • Role of calmodulin in nuclear functions.

2. Signaling and regulation of the cell cycle: In eukaryotic organisms, the response to stress insults is through the activation of the MAP kinases pathway, Progression through the cell cycle is dependent on external stimuli and failure to correctly integrate the induced signals can lead to accumulation of genetic damage contributing to cancer development. Understanding how signaling networks and the cellular responses are regulated is one of the most crucial objectives in biomedical research. The aim of this research focuses on identifying the molecular mechanisms by which cell cycle is regulated by stress-activated protein kinases.

3. Lipid trafficking and storage: The aim of our project is to characterize in health and disease, the cellularprocesses regulated or deregulated by the accumulation of lipids within cells. With a special attention to the cellular cost of accumulation of cholesterol in the organelles and the role of the caveolin protein in the regulation of these mechanisms.