Area 2

Inflammation and repair in respiratory illnesses

Team leader

Strategic objectives

The general objective of the group is to investigate the inflammatory and tissue repair mechanisms in chronic obstructive pulmonary disease (COPD), their clinical-functional correlation, the diagnostic, prognostic and therapeutic implications of such knowledge, and particularly their relevance in relation to pulmonary oncogenesis. COPD is presently the fourth most common cause of death in the world, and will rank third within a decade. Lung cancer is the most common malignant tumor in males (and soon also will be the most common malignancy in females), and involves one of the poorest prognosis with the currently available treatment options. To investigate these objectives the group uses systems network methods.

Main lines of research

  1. Mechanism of abnormal repair in COPD related to the inflammation present in COPD patients (in collaboration with Dr.Ernest Sala, of the Hospital Son Espases, Mallorca).
  2. Mechanisms of oncogenesis in COPD (in collaboration with investigators of the Fundació Caubet-Cimera in Mallorca and the CIBER of respiratory diseases (CIBERES): SINECAN project).
  3. Application of the methodology of systems biology (“omic” platforms and bioinformatics) to COPD, with a view to integrate the cellular and molecular alterations with clinical data. This line is developed in the setting of the CIBER of respiratory diseases (, involving a strategic alliance with the Institute for Systems Biology (Seattle, USA), Harvard University (USA) and the pharmaceutical industry with an interest in COPD