Area 4

Neurobiology Unit

Team leader

  • Ramon Trullàs

Strategic objectives

The Neurobiology Unit investigates molecular mechanisms of excitotoxic and apoptotic neuron death with the objective of identifying new therapeutic targets for the management of neurodegenerative diseases. Another objective is to gain knowledge of the mechanisms regulating neurogenesis in the adult brain.

Main lines of research

  1. Identify new biomarkers for early detection of Alzheimer's disease in the preclinical phase, using a new method of differential proteomic analysis.
  2. Investigation of the function of neuronal pentraxin 1 (NP1) during programmed neuron death, with the hypothesis that inhibition of the expression of this protein may constitute a new treatment for chronic neurodegenerative disorders.
  3. Study the role of mitochondrial DNA and mitochondrial dynamics in neurodegeneration models.
  4. Study of the mechanism by which the KATP channel modulates microglial activity, thereby allowing the in vivo and in vitro characterization of the neuroprotective and neurotoxic effect of microglia in various neurological disorders, through the activation and blockade of this channel.
  5. Investigation of of new genetic variants that modify the extent of microglial activation and neuroinflammation, and that may offer clinical therapeutic benefits for neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) or Alzheimer's disease.
  6. Investigation of the efficacy and safety of anti-A beta immunotherapy as treatment for Alzheimer's disease.